2021
- S Gampala, JY Yang* Hedgehog Pathway Inhibitors against Tumor Microenvironment. Cells. 2021,10(11), 3135
- S Gampala, G Zhang, C Chang, JY Yang*. Activation of AMPK sensitizes medulloblastoma to Vismodegib and overcomes Vismodegib- resistance. FASEB BioAdvances. 2021;00:1–11.
- MR Kim, Y Zhang, MJ Wu, JY Yang*, C Chang*. TET2 Directs Mammary Luminal Cell Differentiation and Endocrine Response. Nature Communications volume 11, Article number: 4642
- Kumari R, Silic MR, Jones-Hall YL, Nin-Velez A, Yang JY, Mittal SK, Zhang G. (2018) Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget. May 4;9(34):23494-23504.
- Wu MJ, Chen YS, Kim MR, Chang CC, Gampala S, Zhang Y, Wang Y, Chang CY, Yang JY, Chang CJ. (2018) Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin. Cell Metabolism 2018 Nov 27. PMID:30527740
- Cui Z, Shen Y, Chen KH, Mittal SK, Yang JY, Zhang G. KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors. Sci Rep. 2017 Jan 9;7:40325. doi: 10.1038/srep40325.PMID: 28067315
- Zhang, R., Huang, S.Y., Li, K., Li, YH, Hsu,WH, Zhang G, Chang CJ, and Yang, JY. Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation. Oncotarget. 2017 Jul 25;8(30):49869-49881.
- Wu MJ, Kim MR, Chen YS, Yang JY, Chang CJ. Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway. Oncogene. 2017 Jun 1;36(22):3193-3206.
- Huang, SY., Chen, SK and Yang JY. Activation of AMPK inhibits medulloblastoma cell growth and GLI1 activity. Cancer Reports and Reviews. 2017 Nov. 30 Vol 2(1):1-4.
- Hensley, MR, Chua RF., Leung YF, Yang, JY, Zhang, G. Molecular evolution of MDM1, a “Duplication-Resistant” Gene in Vertebrates. 2016, Plos One. 2016 Sep 22;11(9):e0163229. PMID:27658201
- Zhang X, Li J, Yang JY, Wood KV, Rothwell AP, Li W, Blatchley Iii ER. Chlorine/UV Process for Decomposition and Detoxification of Microcystin-LR. Environ Sci Technol. 2016 Jul 19;50(14):7671-8. PMID: 27338715
- Hensley MR, Cui Z, Chua RF, Simpson S, Shammas NL, Yang JY, Leung YF, Zhang G. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Sci Rep. 2016 Jun 13;6:27816. PMID: 27292017
- Huang, S.Y.; Yang, JY. Targeting the Hedgehog Pathway in Pediatric Medulloblastoma. Cancers, 2015, 7, 2110-2123.
- Li YH, Luo J, Mosley YY, Hedrick VE, Paul LN, Chang J, Zhang G, Wang YK, Banko MR, Brunet A, Kuang S, Wu JL, Chang CJ, Scott MP, Yang JY. AMP-activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma. Cell Reports, 2015 Jul 28;12(4):599-609.
- Chang CC, Wu MJ, Yang JY, Carmarillo I, Chang CJ. Leptin-STAT3-G9a signaling promotes obesity-mediated breast cancer progression. Cancer Research, 2015 Jun 1;75(11):2375-86.
- Zhang G, Yang JY, Cui Z. New insight into cancer aneuploidy in zebrafish. Int Rev Cell Mol Biol. 2015; 314:149-70.
- Wu PC, Lu JW, Yang JY, Lin IH, Ou DL, Lin YH, Chou KH, Huang WF, Wang WP, Huang YL, Hsu C, Lin LI, Lin YM, Shen CK, Tzeng TY. A H3K9 Methyltransferase, KMT1E, Suppresses Lung Cancer Cell Metastasis Through the SMAD2/3 Pathway. Cancer Research, 2014, Dec 15;74(24):7333-43.
- Chao CH, Chang CC, Wu MJ, KO HW, Wang D, Hung MC, Yang JY, Chang CJ. Dysregulated miR-205 signaling promotes symmetric division of self-renewing mammary stem cells and mammary tumorigenesis (2014) J Clin Invest. doi:10.1172/JCI73351.
- Zhang GJ, Vemulapalli TH, Yang JY (2013) Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution. Applied & Translational Genomics Advanced online publication, http://dx.doi.org/10.1016/j.bbr.2011.03.031
- Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nature Cell Biology. 2011 Jan;13(1):87-94
- Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-b-catenin signaling. Cancer Cell. 2011 Jan 18;19(1):86-100.
- Chang CJ*, Chao CH*, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nature Cell Biology. 2011 Mar;13(3):317-23.
- Ding Q*, Chang CJ*, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, Huo L, Cheng X, Chen YJ, Li CW, Jeng LB, Hsu JL, Li LY, Tan A, Curley SA, Ellis LM, Dubois RN, Hung MC. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis (2011) J Clin Invest. 2011 Nov;121(11):4526-36.
- Yang JY and Hung MC (2011) Deciphering and targeting Forkhead Transcriptional Factors in Cancer Therapy. Current Drug Targets. 2011 Mar 28. [Epub ahead of print] (Invited review)
- Yang JY*, Chang CJ*, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Research. 2010 Jun 1;70(11):4709-18. (*Equal contribution)
- Yang JY, Hung MC. A new fork for clinical application: targeting forkhead transcription factors in cancer. Clinical Cancer Research. 2009 Feb 1;15(3):752-7. Review. (Invited review) 2008
- Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Tsai CH, Sahin AA, Muller WJ, Mills GB, Yu D, Hortobagyi GN, Hung MC et al., ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nature Cell Biology. 2008 Feb;10(2):138-48 (Selected as hi-lite article in News and Views, Nature Cell Biology 10, 125 - 126).
- Yang JY*, Ding Q*, Huo L*, Xia W, Wei Y, Liao Y, Chang CJ, Yang Y, Lai CC, Lee DF, Yen CJ, Chen YJ, Hsu JM, Kuo HP, Lin CY, Tsai FJ, Li LY, Tsai CH, Hung MC. Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Research. 2008 Aug 1;68(15):6109-17. (*Equal contribution)
- Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, Yang JY, Sahin AA, Hortobagyi GN, Tsai FJ, Tsai CH, Hung MC. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 2007 Aug 10;130(3):440-55.
- Yang JY, Xia W, Hu MC. Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int J Oncol. 2006 Sep;29(3):643-8.
- Yang JY*, Zong CS*, Xia W, Wei Y, Ali-Seyed M, Li Z, Broglio K, Berry DA, Hung MC. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Molecular & Cellular Biology. 2006 Oct;26(19):7269-82. (*Equal contribution)
- Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Molecular Cell. 2005 Jul 22;19(2):159-70.
- Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell. 2004 Apr 16;117(2):225-37.
- Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Research. 2004 Dec 15;64(24):9080-5.